Gene expression signatures were developed with in vitro drug sensitivity data and Affymetrix microarray data.
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For example, women have different drug sensitivities depending on which phase of their menstrual cycle they are in.
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For example, two specific versions of this gene are related to increased drug sensitivity among the Han Chinese population.
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Drug sensitivity sometimes varies from patient to patient, even in those infected with seemingly identical strains of the virus.
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M . leprae cannot be grown on routine laboratory culture media, so drug sensitivity testing in vitro is not possible.
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In one study, the drug sensitivity of people who had used temazepam for one to 20 years was no different from that of controls.
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By linking mutations to drug sensitivity, they were able to propose new mechanisms for targeted therapies by examining the accumulation of certain mutations in cancer cells.
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It has been found that dauricine has a minimum drug sensitivity concentration between 3.81-5.15 �g / mL in bladder cancer EJ cells and prostate cancer PC-3M cells.
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By screening with siRNA libraries, researchers can identify genes that alter drug sensitivity in the cellular disease model, thereby providing a way to quickly close in on the molecular targets.
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Areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
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